Clomid Side Effects & PCOS: Breast Tenderness & Ovulation

Question
QUESTION: Hi Dr. Fox,
My OB/GYN prescribed Clomid for me this month because we are trying to conceive.  I have PCOS.  I took the Clomid on days 3-7 of my cycle, but had a positive ovulation test on day 11 (I think it would have maybe been positive on day 10 if I would have tested).  I felt pain on my right side around day 14.  Anyway, my breasts are extremely tender, a lot more than they normally are before I get my period.  Is this related to the Clomid, or could this be an early sign of pregnancy.  I took a test today, and it was negative.  Thanks.

ANSWER: This is related to "better" ovulation stimulated by Clomid- not the drug itself. Most females have tenderness in the Luteal phase- a sign of normal cycle- in pregnancy tenderness presists longer.

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QUESTION: This is cycle day 26 for me.  My period is due to arrive on saturday.  My breasts are still extremely tender at this point.  That is why I was wondering if it could be related to taking Clomid.  I took a pregnancy test today and it was negative.  Any ideas??

Answer
Breast tenderness can occur from many different etiologies. It is therefore extremely important to undergo a clinical breast exam in your physician's office. Many times, "breast pain" may be associated with hormonal changes during the menstrual cycle and therefore keeping a diary of when the pain starts and how it progresses may help your physician determine the reason. Sometimes if further evaluation is necessary and depending upon your personal & family history, additional testing would be warranted.changes during the