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Lisinopril/HCTZ and Lab Test Interference: A Guide for Patients


Question
QUESTION: my husband takes Lisinopril/Hydrochlorathiazide and he just had lab tests to check his thyroid among other things.
I just read on the papers that came with his lisinopril/HCTZ that this medicine may affect certain lab test results including parathyroid function tests. He is also taking Levothyroxin for his thyroid and his tsh has been 0.20 for the last six months which is in the hyper-range. Will the lisinopril/HCTZ cause his lab tests to be inaccurate?

ANSWER: ORIGINAL ANSWER (1/16/08):
Hi Connie, I'd be happy to try and answer your question.  Lisinopril/HCZT is a blood pressure medicine.  The answer to your question is, yes, it may affect certain laboratory tests, such as hemoglobin/hemocrit, liver function tests, uric acid, magnesium, cholesterol, triglycerides, calcium, creatinine, BUN, and electrolytes.  It shouldn't affect his TSH test result.  If there were any abnormal results for any of the tests I mentioned that can be affected, your husband's doctor should be aware that his taking the lisinopril could've caused them.  I hope I've answered your question.  Take care and good luck.

**This answer is not a substitute for professional medical advice.*

ADDED COMMENTS (3/19/08):

Connie,

I was informed of an incorrect answer I gave to your question of whether or not lisinopril/HCTZ can affect thyroid test results.  In the above answer I gave you, I clearly said that "It shouldn't affect his TSH test result."  The sites I researched hadn't mentioned that it could affect TSH results, so I wrongly assumed that it didn't.  In fact lisinopril/HCZT can affect thyroid testing, and your doctor should be informed that you are taking this medicine if he wants to do a thyroid test.  Was your doctor aware of this fact?  If so, then he would have known of this possibility.  I apologize if this caused any inconvenience for you or your husband.  But my disclaimer clearly says that my answers are not substitutes for professional medical advice.

Samantha

---------- FOLLOW-UP ----------

QUESTION: I so appreciate your added comments.  Thank you so much.
Do you happen to know whether it would cause the thyroid
test to be lower or higher?

Answer
Hi again Connie.  When I got the comment from someone who corected my original answer to you, I knew I had to try and contact you again.  Like I said before, I'm sorry if I've caused you or your husband any inconvenience.  I've just been reading up a little on lisinopril/HCTZ and all I can find is that it affects test results, but I can't find whether or not it raises or lowers it.

Samantha

**This answer is not a substitute for professional medical advice.**