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Progesterone Levels in Early Pregnancy: Monitoring & IVF Support


Question
QUESTION: Hi Doctor. I have recently become pregnant after my 7th IVF, and am currently 6 weeks. I had 2 very good quality blastocysts transferred and am awaiting my 7 weeks scan next week to see the heartbeat and hopefully tell if it's twins. I have been going in for blood tests to monitor my progesterone levels and initially I was taking 2 cyclogest (400mgs) a day, it then increased to 3 and now 4 a day. This was because my prog levels were fluctuating from 80 and 150 and my FS feels 150 is a good level. My last test showed it at 200.

From doing my research, I realise that normal prog levels can be anything above 30 and less than 100. Are mine too high? IS there any danger of having prog at 150-200?

My Bhcg has also been monitored every 2-3 days and they have been climbing nicely, from 193,447,1863, 4990 and now 13900. Are those indicative of a viable pregnancy?

Many thanks for your help and advice.

Regards
Nelly

ANSWER: Hello Nelly from the U.K.,

Congratulations.  I'm glad you persevered because most patients would not try IVF 7 times.  All your levels are fine.  Your progesterone is not too high and there is not danger with a level of 200.  I'm surprised your doc is chasing the levels.  Your bHCG levels are great.  With a level of 13,900, the gestational sac should already be visible within the uterus, so your doc should go ahead and do a scan this week rather than wait until next week.  At this point it is important to confirm the uterine pregnancy because there is a 2-5% risk of ectopic pregnancy with IVF (tubal pregnancy).  If it were in the tube, this would be the time to treat it as medication can be used instead of surgery.  I don't mention this to scare you, but I normally do my first ultrasound at 6 weeks gestational age for this reason.  You might want to ask your doctor to do so as well.  More than likely everything will be fine.  Again congratulations.

Good Luck,

Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
www.montereybayivf.com

Monterey, California, U.S.A.

for additional information check out my blog at http://womenshealthandfertility.blogspot.com check me out on twitter with me at @montereybayivf, and follow me on Facebook at http://bit.ly/9Iw9oV


---------- FOLLOW-UP ----------

QUESTION: Hi Doctor

Thanks you so much for your advice, I really appreciate it. I took your advice and scheduled a scan for today, which confirmed a single uterine pregnancy and we saw the heartbeat. So it is a relief!

I am currently 6 weeks and 4 days. Is there any chance of things going wrong after seeing a heartbeat? I haven't had any bleeding or haven't had any major cramping. I also haven't been experiencing nausea and morning sickness, but I have had lower back pain, fatigue, and strangely enough throbbing ankle or feet pain now and then.

Thank you for your time and help.

Regards
Nelly

ANSWER: Hello Nelly,

Congratulations.  At 6 weeks with the findings of a fetus of appropriate size and a good heartbeat, those are good signs for the pregnancy.  There is still a risk of miscarriage that runs about 40% until 8 weeks gestational age.  Your doctor should probably repeat the ultrasound in two weeks.  If everything looks fine at the next ultrasound (8+weeks), then the risk of miscarriage drops to 5% until 12 weeks gestational age.

Of course there are lots of problems that can occur in pregnancy.  Everyone has the same risks.  But if you worried about every possible risk, you would go crazy and not enjoy your pregnancy.  For now, I would recommend that you take things in stride and day to day.  Don't worry about the future because you don't necessarily have control over it.  Hope for the best because that is the most likely outcome.  And as the sailors of olde used to say, pray for good winds!

Good Luck,

Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
www.montereybayivf.com

Monterey, California, U.S.A.

for additional information check out my blog at http://womenshealthandfertility.blogspot.com check me out on twitter with me at @montereybayivf, and follow me on Facebook at http://bit.ly/9Iw9oV


---------- FOLLOW-UP ----------

QUESTION: Thanks again for your informed response Doctor. It is really re-assuring to get advice from a professional. I am now awaiting my 8 week scan and fingers crossed that everything will be okay.

In the meantime I am still taking my progesterone pessaries, and since I have been on the corticosteroid protocol, I am also taking prednisolone and clexane daily until 12 weeks.

You are right, one can worry about the pregnancy all day long, but that would drive a person crazy. I'm trying to just not focus on it solely, and going on with day to day life...until our next appt or scan.

Hope you don't mind if I keep in touch with my progress.

thanks and regards
nelly

Answer
Hello Again,

I'm glad that things are going well and hope that the 8 week scan will be reassuring and put your fears at rest.  I don't quite agree with the corticosteroid protocol at this point.  I don't think I can recommend continuing it any further, and definitely not until 12 weeks.  It can have a potential effect on the fetal adrenal glands, especially at this point in the development.  You might want to discuss this further with your doctor.

I certainly don't mind hearing back about your progress if you wish.  This forum is probably not the best place for that.  I would recommend that you either contact me via my blog or use my email, as given in my website.  Enjoy your pregnancy.

Sincerely,

Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
www.montereybayivf.com

Monterey, California, U.S.A.

for additional information check out my blog at http://womenshealthandfertility.blogspot.com check me out on twitter with me at @montereybayivf, and follow me on Facebook at http://bit.ly/9Iw9oV