PSA Test Accuracy: Do Medications Affect Results?

Question
Do any prescription drugs artificially raise lab test results for psa?
i.e. you get false results or the drug itself raises the psa, which is interpretated clinically as sinister?

many thanks
JB

Answer
Hi John, I'd be glad to try and answer your question.  A falsely high PSA is fairly common.  Prostate manipulation by biopsy or resection of the prostate will significantly elevate PSA levels. The blood test should be done before surgery or six weeks after manipulation. Rigorous physical activity affecting the prostate, such as bicycle riding, may cause a temporary rise in PSA levels. Excessive doses of some chemotherapeutic drugs, such as cyclophosphamide and methotrexate, may increase or decrease PSA levels. In some men, PSA may rise temporarily due to other prostate conditions, especially infection. A recent study found that in about half of men with a high PSA, values later return to normal. Some authorities recommend that a high PSA should be repeated (between 6 weeks and 3 months after the high PSA) before taking any further action.  

Samantha

**This answer should not be viewed as a substitute for a doctor's care!**