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Depo-Provera and Fertility: A Patient's Experience & Concerns


Question
About 2 years ago, I began having serious problems. We were TTC, and could NOT get pregnant!
So I began all the usuals, paps, birth control pills for regulation, everything! Nothing seemed to work. In November of '03, I began seeing a Family Practicioner about the SEVERE pelvic pain I was having. He said he thought I had endometriosis, and began me on a treatment of Depo-Provera for the pain associated with Endo. Here is where I have a problem. The normal dose of Depo is 150cc every 3months. He was injecting me with 100cc's every 2 weeks! He said he would continue this 4 times, then move it to 100cc's every 4 months. Since this man is a DOCTOR, i think nothing of it. I stopped taking the depo on Dec 17th, as he wanted me to start self-injection, and I could not. Pelvic pain is still there, but on March 11th I started having some kind of vaginal bleeding/discharge, but it wasnt red or white, it was more like BLACK. every day I have this problem, until 2 days ago, now its blood. I have been having symptoms of a stroke, and problems breathing, and I am not sure if this is due to an OVERDOSE of Depo, or what? Have I been overdosed? What can I do to find out? I have had a NORMAL ultrasound, and a NORMAL pap since this. Thank You for all your help!

Answer
Hi Lici,
I think that your bleeding issues come from the abrupt withdrawl from the hormone therapy. In view of your normal PAP and ultrasound, I wouldn't worry about it. Did your pelvic pain go away with the injections? If so I'd try to do self injections to keep the endometrosis under control.
There is a certain amount of latitude with hormone dosing as different patients respond differently to hormones. A 'loading dose' such as you described isn't considered an overdose.