Questionhi dr aukerman,
i happened upon your response to a broad question on juvenon.
http://experts.about.com/q/Family-Internal-Medicine-969/Juvenon.htm
my father is bruce ames, who invented the mixture, and having heard so many enthusiastic things from him, i was a bit surprised to see you discount juvenon out of hand, and for theoretical rather than clinical reasons. i actually take it and find i get a significant energy lift, though i understand it doesn't work for all people. (my father, ironically, doesn't feel any change)
i'm not a scientist so can't respond to your metabolic argument, but i believe that
http://www.juvenon.com/science/research.htm discusses actual double-blind studies that showed a significant positive result from taking the mixture. there are also a number scientific papers written dealing with the research leading up to juvenon.
while i'm sure that the method you list is also quite helpful, it might be fair, in light of the studies, to not discount his research soley on the basis of theory, even though it might not align fully with your own thoughts.
perhaps you would consider amending your answer?
thanks very much,
matteo
AnswerMy apologies to your father, no doubt in mind he is one of the greatest scientists in applied nutrition today, bar none.
In respect for your father, I reviewed all the literature available on the Website but still am left with a concern that maybe your original question was looking for an endorsement of a product. I am sorry I was unable to do that if by chance that was your desire.
That not withstanding, and with the greatest respect for your father, the great research he performed has not been fully duplicated in humans for lots of reasons, I am sure.
Much of my clinical work with very depleted people and my countless hours of detailed research on the relevant literature to date had confirmed my judgment that rat and mice research does not always relate to humans since humans can not convert (PUFAs and many other) nutritional elements in the way rats and mice can.
A good but not directly related example is the Flax fad supported solely by excellent rat and mice research but totally useless (and potentially dangerous) in humans because of the great metabolic difference in their liver potentials compared to humans.
If your father is living give him my most sincere and heartfelt thanks for all his great work, especially on the potential for high dose vitamins to reverse 50 genetic diseases, which article I refer to daily with patients.
If he is not living send him my thoughts and most sincere reverence.
I even thought of trying the product on some patients but they could not afford the cost and we are a practice center without funds or staff for research.
Have a great week ahead.
Glen Aukerman, MD,
FACPM, FAAFP, DABHM, DABFP
Medical Director
614-293-9777, 9677 fax
The Ohio State University Center for Integrative Medicine
2000 Kenny Road
Columbus, Ohio 43221
