Diflucan & Cipro During Pregnancy: Potential Risks & Concerns

Question
Hello, my wife aged 30 ~200lbs (90KG) who has never had any children was treated for a vaginal yeast and UTI infection with both Diflucan-150 and CIPRO 250. She took the Diflucan on the 1st day of her menstrual cycle, 1 dose of Diflucan-150 1 time only. She also took 12 doses of CIPRO-250 for 6 days (twice daily). She is now late menstruating and an over the counter pregnancy test comes back positive.  Can the fact that she took these drugs cause problems to the fetus?

Answer
Diflucan (fluconazole) is an antigungal agent. In studies with pregnant rabbits, abortions were noted at a dose 20-60 times the recommended human dose, but no fetal anomalies.   Published experience with the use of smaller doses, such as those prescribed for vaginal fungal infections, suggests that the risk for adverse outcomes is low, if it exists at all.  Cipro can be safely used during pregnancy and does not cause any embryotoxic effects. Don't worry about the medications that your wife took.