* UV Radiation Damage: Prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds can cause sunburn, premature aging (wrinkles, age spots), and increase the risk of skin cancer.
* Mechanical Damage: Physical trauma to the skin, such as cuts, scrapes, bruises, and pressure ulcers (bedsores), can disrupt the skin's barrier function and lead to inflammation, infection, and scarring.