QuestionI am currently undergoing infertility treatment in Taiwan. I was stimulated with gonal-f and hcg, and I am currently on day 8 after intercourse. Initially I was put on a vaginal progesterone cream Crinone 8%, but since I did not tolerate it well (spot bleeding, itchiness and lots of discharge), my doctor put me on progesterone injection as of yesterday. Unfortunately, the nurses misread the prescription (!), and I was administered an injection of 125 mg progesterone whereas the doctor had prescribed 50 mg. A few hours after the shot I was exteremely dizzy and had a huge migraine... today I again have a bit of spot bleeding. I took the the daily 50 mg injection this morning and feel ok now. My question to you is whether this large dosis of progesterone I had yesterday can do any harm to the overall project of a healthy pregnancy? (My medical treatment is conducted in Chinese, and though I speak it well, I find my questions to the doctor mostly go unanswered). Thank you for your time.
AnswerHello Inge from Taiwan,
I don't think that the amount of progesterone that you received is of sufficient dosage to interfere with your chances of pregnancy. I often double up on my progesterone dose with my IVF patients. They receive both injectable progesterone (50 mg) and vaginal Crinone 8% or Endometrin 100 mg twice per day. I do this to prevent implantation failure due to inadquate endometrial development from a lack of b-integrins, because the treatment for inadequate b-integrins, proteins that are required for implantation, is to increase the progesterone.
Good Luck,
Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
www.montereybayivf.com
Monterey, California, U.S.A.
for additional information check out my blog at http://womenshealthandfertility.blogspot.com check me out on twitter with me at @montereybayivf and facebook @montereybayivf
