* Rabbits: Often used in Draize tests to assess eye and skin irritation. These tests can involve applying substances to a rabbit's shaved skin or placing them in their eyes, then monitoring for signs of damage.
* Guinea pigs: Similar to rabbits, guinea pigs are used for skin sensitization tests to identify if a substance causes an allergic reaction.
* Mice and Rats: Used in a variety of tests, including acute toxicity tests (to determine if a single exposure to a substance is harmful), repeated-dose toxicity tests (to assess the effects of prolonged exposure), and carcinogenicity tests (to see if a substance causes cancer).
* Fish: Used to test the impact of cosmetic ingredients on aquatic environments.