* Ancient Mesopotamia: Around 5,000 years ago, Mesopotamian women crushed gemstones and used them to decorate their lips.
* Ancient Egypt: Egyptians, including Cleopatra, used red dye derived from fucus-algin, 0.01% mannite, and bromine to color their lips.
So, while it's hard to say definitively which civilization created the "first" lipstick, both Mesopotamia and Ancient Egypt have strong claims to its early use.